Revealing effects of psychosocial factors of cancer patients

Abstract. This research shows different methodologies applied on different platforms in order to extract both social and psychosocial factors that might be related to caner by applying natural language processing tools on text from different platforms as social media or other online forums. We also present challenges associated with every platform and the corresponding tools used on it. From text mining to text analysis and then data visualisation, this research compares different analysis methods and outputs. We discuss many tools either tested, used or modified in order to achieve such analysis. Meanwhile, we were able to get interesting findings for the medical fields to explore and research more. We developed a modular system that can help clinicians and medical experts use to analyse similar forums.Syöpäpotilaiden psykososiaalisten tekijöiden vaikutusten paljastaminen. Tiivistelmä. Tämä tutkimus esittelee erilaisia menetelmiä sovellettuina eri alustoilla, tavoitteena hahmottaa sekä sosiaalisia että psykokososiaalisia tekijöitä, jotka voivat liittyä syöpään sovellettaessa luonnollisia kielenkäsittelyvälineitä eri alustojen tekstille sosiaalisen median tai muiden online-foorumeiden muodossa. Esitämme myös haasteita, jotka liittyvät jokaiseen alustaan ja siihen liittyviin työkaluihin. Teksti-mining, tekstianalyysiin ja sitten datan visualisointiin tässä tutkimuksessa verrataan erilaisia analyysimenetelmiä ja -tuloksia. Keskustelemme monista työkaluista, jotka on testattu, käytetty tai muunnettu tällaisen analyysin saavuttamiseksi. Samaan aikaan saimme mielenkiintoisia tuloksia lääketieteen aloille tutkia ja tutkia lisää. Kehitimme modulaarisen järjestelmän, jonka avulla lääkärit ja lääketieteen asiantuntijat voivat analysoida samanlaisia foorumeita

A new simple route for synthesis of cadmium(II), zinc(II), cobalt(II), and manganese(II) carbonates using urea as a cheap precursor and theoretical investigation

ABSTRACT. The MnCO3.H2O, CoCO3.4H2O, ZnCO3, and CdCO3, respectively, were synthesized through a new precise, easy pathway for the reaction of MnI2, CoI2, ZnI2, or CdI2 aqueous solutions with a cheap precursor-urea for 10 h at ~ 70 oC. The IR spectra of reaction products designate the presence of characteristic bands of ionic carbonate, CO32– and absence of the individual bands of urea. The (CO3)2- ion is planar and therefore, it belongs to the D3h symmetry. It is expected to display four modes of vibrations. The stretching vibrations of the type; n(C-O) is observed in the range of (1376-1503) cm-1 while another stretching vibration n(C-O) is observed in the region 1060-1079 cm-1. The out of plane of vibration d(OCO) is observed in the range of (833-866) cm-1 while, the angle deformation bending vibration d(OCO) appear in the range of (708-732) cm-1. The infrared spectra of metal carbonate, show that, this product clearly has an uncoordinated water. The band related to the stretching vibration n(O-H) of uncoordinated H2O is observed as expected in the range of ~ 3000 cm-1. A general mechanism explaining the synthesis of carbonate compounds of cadmium(II), zinc(II), cobalt(II), and manganese(II), are described. Moreover, the DFT outcomes using B3LYP/LanL2DZ (basis set) agree with the experimental results.                 KEY WORDS: Carbonate, CoI2, Infrared spectra, Urea, DFT   Bull. Chem. Soc. Ethiop. 2022, 36(2), 363-372.                                                                DOI: https://dx.doi.org/10.4314/bcse.v36i2.10                                                     &nbsp

New Mononuclear and Binuclear Cu(II), Co(II), Ni(II), and Zn(II) Thiosemicarbazone Complexes with Potential Biological Activity: Antimicrobial and Molecular Docking Study

Herein, we report the synthesis of eight new mononuclear and binuclear Co2+, Ni2+, Cu2+, and Zn2+ methoxy thiosemicarbazone (MTSC) complexes aiming at obtaining thiosemicarbazone complex with potent biological activity. The structure of the MTSC ligand and its metal complexes was fully characterized by elemental analysis, spectroscopic techniques (NMR, FTIR, UV-Vis), molar conductivity, thermogravimetric analysis (TG), and thermal differential analysis (DrTGA). The spectral and analytical data revealed that the obtained thiosemicarbazone-metal complexes have octahedral geometry around the metal center, except for the Zn2+-thiosemicarbazone complexes, which showed a tetrahedral geometry. The antibacterial and antifungal activities of the MTSC ligand and its (Co2+, Ni2+, Cu2+, and Zn2+) metal complexes were also investigated. Interestingly, the antibacterial activity of MTSC- metal complexes against examined bacteria was higher than that of the MTSC alone, which indicates that metal complexation improved the antibacterial activity of the parent ligand. Among different metal complexes, the MTSC- mono- and binuclear Cu2+ complexes showed significant antibacterial activity against Bacillus subtilis and Proteus vulgaris, better than that of the standard gentamycin drug. The in silico molecular docking study has revealed that the MTSC ligand could be a potential inhibitor for the oxidoreductase protein.Taif UniversityPeer Reviewe

D4.2 Intelligent D-Band wireless systems and networks initial designs

This deliverable gives the results of the ARIADNE project's Task 4.2: Machine Learning based network intelligence. It presents the work conducted on various aspects of network management to deliver system level, qualitative solutions that leverage diverse machine learning techniques. The different chapters present system level, simulation and algorithmic models based on multi-agent reinforcement learning, deep reinforcement learning, learning automata for complex event forecasting, system level model for proactive handovers and resource allocation, model-driven deep learning-based channel estimation and feedbacks as well as strategies for deployment of machine learning based solutions. In short, the D4.2 provides results on promising AI and ML based methods along with their limitations and potentials that have been investigated in the ARIADNE project

Mortality of emergency abdominal surgery in high-, middle- and low-income countries

Background: Surgical mortality data are collected routinely in high-income countries, yet virtually no low- or middle-income countries have outcome surveillance in place. The aim was prospectively to collect worldwide mortality data following emergency abdominal surgery, comparing findings across countries with a low, middle or high Human Development Index (HDI). Methods: This was a prospective, multicentre, cohort study. Self-selected hospitals performing emergency surgery submitted prespecified data for consecutive patients from at least one 2-week interval during July to December 2014. Postoperative mortality was analysed by hierarchical multivariable logistic regression. Results: Data were obtained for 10 745 patients from 357 centres in 58 countries; 6538 were from high-, 2889 from middle- and 1318 from low-HDI settings. The overall mortality rate was 1⋅6 per cent at 24 h (high 1⋅1 per cent, middle 1⋅9 per cent, low 3⋅4 per cent; P < 0⋅001), increasing to 5⋅4 per cent by 30 days (high 4⋅5 per cent, middle 6⋅0 per cent, low 8⋅6 per cent; P < 0⋅001). Of the 578 patients who died, 404 (69⋅9 per cent) did so between 24 h and 30 days following surgery (high 74⋅2 per cent, middle 68⋅8 per cent, low 60⋅5 per cent). After adjustment, 30-day mortality remained higher in middle-income (odds ratio (OR) 2⋅78, 95 per cent c.i. 1⋅84 to 4⋅20) and low-income (OR 2⋅97, 1⋅84 to 4⋅81) countries. Surgical safety checklist use was less frequent in low- and middle-income countries, but when used was associated with reduced mortality at 30 days. Conclusion: Mortality is three times higher in low- compared with high-HDI countries even when adjusted for prognostic factors. Patient safety factors may have an important role. Registration number: NCT02179112 (http://www.clinicaltrials.gov)

Essays on Applications of Sentiment Analysis and Text Mining Techniques in Online Reviews

Social Influence in Hotel Reviews: The Effect of Emotions and Hotel Characteristics. A longitudinal analysis to monitor changing patterns of hotel customers' perceptions using Topic modelling and sentiment analysis. Social influence through prior mode rating: The moderating role of geographical proximity and expertise of reviewer

Spectroscopic and Characterization of Medical and Physical Applications of Metal Complexes of Schiff bases in nano-sized Shape: Mg(II), Ca(II) and Ba(II) Schiff base Complexes

O thatHL is the Schiff base moiety formed from condensation of 2-thiophenecarboxaldehyde with 2-chlorophenyl hydrazine have been prepared and characterized by elemental analysis and spectroscopic measurements (infrared and 1 H-NMR). Elemental analysis of the complexes suggests the stoichiometry is 1:2 (metalligand). Infrared spectra of the complexes agree with the coordination to the central metal atom through the nitrogen of the 2-chlorophenyl hydrazine(-Ph-NH-) group and the sulfur atom of the thiophene ring. Biological properties of prepared compounds were studied included antimicrobial activity and cytotoxicity. A potent antimicrobial activity evaluated by disc inhibition zone and variety degree of activity recorded against gram-positive; gram-negative and fungal strains. Cytotoxicity against two cell lines; MCF-7 and HePG-2 were evaluated and IC 50 values were calculated. The [Ba(HL) 2 (H 2 O) 2 ].Cl 2 .2H 2 O and [Mg(HL) 2 (Cl) 2 ].6H 2 O had the highest antitumor effect with IC 50 values; 32.6 and 30.4µg/ml for MCF-7 cell line and 37.5 ; 39.5 µg/ml for HePG-2 cell line. . Keywords: Spectroscopic, alkaline earth metal complexes, Schiff base. I. INTRODUCTION Schiff base ligands are considered &quot;privileged ligands&quot; because they are easily prepared by the condensation between aldehydes and imines. Stereogenic centers or other elements of chirality (planes, axes) can be introduced in the synthetic design. Schiff base ligands are able to coordinate with many different metals [1], and to stabilize them in various oxidation states. The Schiff base complexes have been used in catalytic reaction

Letrozole versus laparoscopic ovarian drilling in infertile women with PCOS resistant to clomiphene citrate

Objective: To compare the efficacy of letrozole and laparoscopic ovarian drilling (LOD) in the induction of ovulation in women with clomiphene citrate (CC)-resistant polycystic ovary syndrome (PCOS). Subjects and methods: A total of 80 women with CC-resistant PCOS were enrolled and randomly allocated into groups A and B. Group A (n = 40) underwent LOD, and group B (n = 40) received 2.5 mg letrozole from days 3 to 7 of menses for up to six cycles. A 6-month follow-up was performed. Results: No statistically significant differences were found in the baseline clinical characteristics and the major serum hormone profiles, women receiving letrozole had a higher rate of ovulation (70 vs. 57.5%) and however, the differences were not statistically significant also there is significant decrease in MAH in group A. The pregnancy rate was 27.5% in group A versus 35% in group B and abortion rate was 18% in group A versus 7% in the other group. Conclusion: Letrozole had superior reproductive outcomes compared with LOD in women with CC-resistant PCOS and seems to be a suitable first-line ovulation induction instead of LOD in those patients

Synthesis and Characterization of Some New Coumarin Derivatives as Probable Breast Anticancer MCF-7 Drugs

This study aimed to synthesize quinolinone derivatives and investigate their cytotoxic activity. The compound 1-azacoumarin-3-carboxylic acid (2-oxo-1H-quinoline-3-carboxylic acid) was obtained via the cyclocondensation of 2-hydroxybenzaldehyde with diethyl malonate in base catalyst to give ethyl coumarin-3-carboxylate, followed by the ammonolysis of ester (ethyl coumarin-3-carboxylate) with ammonia in the presence of anhydrous potassium carbonate. Treatment of 2-oxo-1H-quinoline-3-carboxylic acid with acetic anhydride, cinnamaldehyde, cinnamic acid and methyl 5-phenyl-2-cyano-2,4-pentadienoate under different conditions led to the formation of 1 (substituted) aza coumarin-3-carboxylic acids (1-N-(acetyl)-azacoumarin-3-carboxylic acid, 1-N-(2-Formyl-1-phenyl) vinyl-azacoumarin-3-carboxylic acids, 1-N-[2-(Hydroxy) carbonyl-1-(Phenyl) vinyl]-azacoumarin-3-carboxylic acid and 1-N-(4-Cyano-5-methoxy-5-oxo-1-Phenylpenta-1,3-diene-1-y)-azacoumarin-3-carboxylic 284 acid), respectively. The structures of synthesized 1-(substituted) azacoumarin-3-carboxylic acids were confirmed based on spectroscopic methods (IR and NMR), along with elemental analyses. Interestingly compound 6 demonstrated probable impacts as an anti-cancer drug against the MCF-7 cell line. The mechanism of action was assessed using a flow cytometric assay. The outcomes revealed that compound 6 could arrest the cell cycle at G2/M phase and pre-G1 apoptosis

Mining health discussions on Suomi24

Abstract This paper discusses an effective way to fuse multiple tools to make a modern and easy-to-use software to get some key findings about health related topics on online social platforms, with a special focus on the famous Finnish forum, Suomi24. Several natural language processing have been tested and, sometimes, modified in order to accommodate the Finnish language linguistic structure and achieve our tasks of mining the health discussion content. We also explore the ability to monitor and track diseases in Finish open discussion forum. The developed modular system can help clinicians and medical experts to analyze similar forums to identify and track related events that can be correlated with hospital dataset in order to generate new hypotheses that initiate future treatment based approaches